Physical behavior of pneumolysin.
نویسندگان
چکیده
Pneumolysin behaved as an acidic protein having an isoelectric pH of 4.9, a molecular weight of approximately 63,000, and a sedimentation coefficient of approximately 4.3.
منابع مشابه
Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.
Pneumolysin, a multifunctional toxin produced by all clinical isolates of Streptococcus pneumoniae, is strongly implicated in the pathogenesis of pneumococcal bronchopneumonia and septicemia. Using isogenic mutant strains, we examined the effect of deletion of the cytotoxic activity or complement-activating activity of pneumolysin on bacterial growth in lungs and blood, histological changes in ...
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Pneumolysin has been identified as a virulence factor in Streptococcus pneumoniae disease. In addition to producing tissue injury through its cytolytic effect, pneumolysin might injure tissues indirectly by eliciting an inflammatory response. We demonstrate for the first time that pneumolysin is a rapid and potent activator of cellular phospholipase A in bovine pulmonary artery endothelial cell...
متن کاملApoptosis induced by pneumolysin in human endothelial cells involves mitogen-activated protein kinase phosphorylation.
Pneumolysin (Ply) is an essential virulence factor of S. pneumoniae, which can induce apoptosis in a variety of host cells to facilitate infection of pathogenic bacteria by as yet unclear mechanisms. To confirm the apoptosis-inducing properties of pneumolysin in endothelial cells, human umbilical vein endothelial cells (HUVECs) were exposed to pne...
متن کاملProtection against bacteremic pneumococcal infection by antibody to pneumolysin.
Pneumolysin is an important virulence factor of Streptococcus pneumoniae. This study examined the hypothesis that human antibody to pneumolysin provides protection against pneumococcal infection. At the time of hospital admission, patients with nonbacteremic pneumococcal pneumonia had higher levels of serum anti-pneumolysin IgG than did patients with bacteremic pneumococcal pneumonia or uninfec...
متن کاملمقایسه سطح آنتی‌بادی پنومولیزین سرمی و آنتی‌ژن پنوموکک ادراری (بیناکس) در کودکان مبتلا به عفونت تنفسی فوقانی و کودکان سالم
Background: Streptococcus pneumoniae is a common cause of respiratory infection. Pneumococcal upper respiratory tract infection (URTI) in children is seldom bacteremic. Determination the prevalence of S.pneumoniae infections in children with URTI using rapid urinary antigen test (BINAX now) and titration of serum pneumolysin antibody (added to conventional culture) was the object of this study....
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 98 1 شماره
صفحات -
تاریخ انتشار 1969